ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria |
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Authors: | Tokuji Kimura |
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Institution: | (1) Dept. of Chemistry, Wayne State University, 48202 Detroit, MI, USA |
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Abstract: | Summary Adrenocortical mitochondrial cholesterol side chain cleavage reactions are regulated by the influence of pituitary ACTH. The
mechanism of the stimulation involves adenyl cyclase, cAMP-dependent protein kinase, cholesterol esterase, and ribosomal labile
protein synthesis. Through these reactions the stimulus reaches the mitochondrial side chain cleavage enzyme system. In this
review article, the current implications on the stimulus transfer from the plasma membrane to the mitochondrial inner membrane
are summarized. In particular the availability of cholesterol to P-450scc was discussed in terms of the distribution of cholesterol molecules in the membranes. |
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