The avermectin-producing Streptomyces avermitilis possesses an inducible valine dehydrogenase |
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Authors: | Kien Trung Nguyen Lieu Thi Nguyen Vladislav Běhal |
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Institution: | (1) Institute of Microbiology, Academy of Sciences of the Czech Republic, Víde ská 1083, 142 20, 4 Prague, Czech Republic |
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Abstract: | Summary Valine dehydrogenase (VDH) is believed to be absent in Streptomyces avermitilis. In the present study, a VDH (M
r, 72 000) was detected by activity measurement and activity staining on a native-PAGE gel. The enzyme activity was induced by L-valine and repressed by ammonia. VDH activity was found to be significantly lower than L-valine transaminase activity. The results suggest that one active VDH does exist in S. avermitilis, and plays a role in valine catabolism and avermectin biosynthesis. |
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