Antimalarial compounds from Schefflera umbellifera |
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Authors: | XS Mthembu FR Van Heerden G Fouché |
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Institution: | 1. Council for Scientific and Industrial Research, Biosciences, PO Box 395, Pretoria 0001, South Africa;2. School of Chemistry, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa |
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Abstract: | The organic extract of the leaves of Schefflera umbellifera exhibited good antimalarial activity when tested against the chloroquine-susceptible strain (D10). Bioassay-guided fractionation of the dichloromethane fraction of the dichloromethane/methanol extract yielded an active compound, betulin, which exhibited good antiplasmodial activity with an IC50 value of 3.2 µg/ml. The reference compound, chloroquine gave an IC50 value of 27.2 ng/ml. Two other compounds were also isolated from the dichloromethane extract namely, 7-hydroxy-6-methoxycoumarin and ent-kaur-16-en-19-oic acid. These two compounds did not exhibit any significant antiplasmodial activity. |
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Keywords: | Antiplasmodial activity Betulin ent-kaur-16-en-19-oic acid Plasmodium falciparum Schefflera umbellifera |
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