Generation of reactive oxygen species by polymorphonuclear leukocytes and its modulation by calcium ions during tumor growth |
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| Authors: | Pustovidko A V Potselueva M M Evtodienko Y V |
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| Affiliation: | Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region, Russian Federation. |
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| Abstract: | The generation of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMNL) and the role of Ca2+ in regulating their activity during Zajdela hepatoma growth in the animal peritoneal cavity were studied. We found a marked increase in the ROS-generating activity of PMNL in circulating blood, the result of increases in both the specific activity of leukocytes and total number of PMNL in circulating blood. The ROS-generating activity of PMNL was substantially activated by Ca2+ ions and a calcium ionophore (ionomycin), but this effect virtually completely disappeared during tumor growth. Perhaps the high ROS-generating activity of PMNL and the lack of the sensitivity to extracellular Ca2+ during tumor growth in the organism are due to an accumulation of intracellular Ca2+ ions. |
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