The role of apoptosis in the development and function of T lymphocytes |
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Authors: | Zhang Nu Hartig Heather Dzhagalov Ivan Draper David He You Wen |
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Institution: | Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. |
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Abstract: | Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work to- gether to regulate T lymphocyte development and function. |
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Keywords: | thymocyte effector memory T lymphocytes apoptosis |
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