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Allelic variants of human calcitonin receptor in the Japanese population |
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| Authors: | M. Nakamura Zhi-qiang Zhang Liang Shan Tomoyuki Hisa Mitsuyo Sasaki Ryuichi Tsukino Toyoharu Yokoi Akio Kaname Kennichi Kakudo |
| Affiliation: | (1) Second Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053, JP;(2) Department of Pediatrics, Wakayama Medical College Kihoku Hospital, Wakayama, 649-71 Japan, JP;(3) Department of Pediatrics, Arita City Hospital, Wakayama, 649-03 Japan, JP;(4) Kaname Clinic, Wakayama, 647 Japan, JP |
| Abstract: | Evidence from cDNA cloning has shown that calcitonin receptors (CTRs) have seven potential transmembrane domains. In this study, structural analysis of CTRs from ten cultured human tumor cell lines and 117 human blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as the 463rd amino acid. It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population. Received: 21 June 1996 |
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