| Abstract: | Utilization of general morphological, histochemical, morphometric and electron microscopic methods revealed marked structural changes of the liver in experimental chronic hepatitis and its subsequent correction with benzonal. The drug administration results in reversibility of the process due to significant action of cellular, and especially intracellular regenerative processes. The latter is supported by the presence of 2 types of cells, the 1st of which are characterized by predominant mitochondrial hypertrophy and hyperplasia suggesting increase in hepatocyte energy activity and the 2nd ones by hypertrophy of the elements of the smooth reticulum responsible for metabolism of foreign body substances being typical for the action of inductors of hepatic microsomal enzymes. |
