|
|||||
|
|
Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain |
|
| Authors: | Machado-Vieira Rodrigo Schmidt André P Avila Thiago T Kapczinski Flávio Soares Jair C Souza Diogo O Portela Luis Valmor C |
| Affiliation: | a Mood Disorders Program, HMIPV, Fundação Faculdade Federal de Ciências Medicas de Porto Alegre, RS, Brasil b Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil c Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil d Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA |
| Abstract: | Bipolar disorder is a chronic and severe mental disorder. Recently, new animal models have emerged to further investigate underlying mechanisms of bipolar disorder such as ouabain-induced hyperactivity in rats. In this study, we investigated the cerebrospinal fluid levels of S100B protein as a putative marker of astrocytic activity in bipolar mania induced by intracerebroventricular administration of ouabain in rats. Ouabain induced a two-fold increase in crossing responses in the open field test and increased 30% the cerebrospinal fluid concentration of S100B, as compared to vehicle group. Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania. |
| Keywords: | Bipolar disorder Ouabain S100B protein Glial cells Mania |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |