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Multivalent methionine‐functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR
Authors:Yang Wu  Wei Zhang  Tinghan Li  Rong Ma  Dan Chen  Junying Zhang  Jianzhong Wu  Jinhai Tang
Affiliation:1. Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China;2. Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, China;3. Jiangsu Key Laboratory of Drug Design and Optimization and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China;4. Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China
Abstract:
Keywords:gene delivery  P glycoprotein  RAFT polymerization  siRNA  tumor targeting
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