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Facile Synthesis of N α -Protected Amino/Peptide Hydroxamic Acids Mediated by COMU |
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| Authors: | Nageswara Rao Panguluri Basavaprabhu Vommina V Sureshbabu |
| Institution: | 1. No. 109, Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore, 560 001, India |
| Abstract: | One-pot preparation of N α -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization. |
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