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An Efficient and Epimerization Free Synthesis of C-Terminal Arylamides Derived from α-Amino Acids and Peptide Acids via T3P Activation |
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| Authors: | Chilakapati Madhu Panguluri NageswaraRao N Narendra Vommina V Sureshbabu |
| Institution: | 1. #109, Peptide Research Laboratory, Department of Studies in Chemistry, Bangalore University, Central College Campus, Dr. B. R. AmbedkarVeedhi, Bangalore, 560 001, India |
| Abstract: | A high yield and rapid synthesis of enantiomerically pure N α -protected amino/peptide acid arylamides using n-propylphosphonic anhydride (T3P) in presence of N-methylmorpholine is described. The generality of the reaction has been studied for various N α -protected amino acids with diverse range of aromatic amines and coumarin derivatives. |
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