Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region. |
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| Authors: | O Sanal S Wei T Foroud U Malhotra P Concannon P Charmley W Salser K Lange and R A Gatti |
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| Institution: | Department of Pathology, University of California, Los Angeles 90024. |
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| Abstract: | We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1. The present paper describes further mapping of the AT locus by means of a panel of 10 markers that span approximately 60 cM in the 11q22-23 region centered around S144 and THY1. Location scores indicate that three contiguous subsegments within the S144-THY1] segment, as well as three contiguous segments telomeric to THY1, are each unlikely to contain the AT locus, while the more centromeric STMY-S144] segment is most likely to contain the AT locus. These data, together with recent refinements in the linkage and physical maps of 11q22-23, place the AT locus at 11q23. |
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