Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase |
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| Authors: | Soldo Blazenka Lazarevic Vladimir Pooley Harold M Karamata Dimitri |
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| Institution: | Institut de Génétique et de Biologie Microbiennes, CH-1005 Lausanne, Switzerland. |
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| Abstract: | The Bacillus subtilis thermosensitive mutant ts-21 bears two C-G-->T-A transitions in the mnaA gene. At the nonpermissive temperature it is characterized by coccoid cell morphology and reduced cell wall phosphate content. MnaA converts UDP-N-acetylglucosamine into UDP-N-acetylmannosamine, a precursor of the teichoic acid linkage unit. |
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