Cloning of rabbit uricase cDNA reveals a conserved carboxy-terminal tripeptide in three species |
| |
| Authors: | K Motojima S Goto |
| |
| Institution: | Department of Biochemistry, Faculty of Pharmaceutical Science, Toho University, Funabashi, Japan. |
| |
| Abstract: | cDNA clones encoding uricase have been isolated from a rabbit liver cDNA library. The nucleotide sequences of the cDNAs have been determined and those of the rat uricase cDNA have been revised. In all three uricases, the carboxy-terminal tripeptides are Ser-Arg/Lys-Leu sequences, which have recently been suggested as an essential element of peroxisomal targetting signals for many but not all peroxisomal proteins. |
| |
| Keywords: | |
|
|
