Development of tetracycline-serratiopeptidase-containing periodontal gel: Formulation and preliminary clinical study |
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Authors: | Manish Maheshwari Gunjan Miglani Amita Mali Anant Paradkar Shigeo Yamamura Shivajirao Kadam |
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Institution: | (1) Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, 411038 Pune, Maharashtra State, India;(2) Department of Periodontology, Dental College and Hospital, Bharati Vidyapeeth Deemed University, Pune, Maharashtra State, India;(3) School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan |
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Abstract: | The purpose of this research was to reduce the polymer concentration and to obtain reasonable viscosity at a lower concentration
of pluronic by the addition of a viscosity modifier. A 20% wt/wt pluronic gel was prepared on a weight basis using the cold
method. The effect of the amount of tetracycline and Aerosil on gel properties was studied. The gel was evaluated using different
parameters: polarizing microscopy, gelation, gel melting, bioadhesivity, viscosity, drug release, and stability of enzyme.
An in vivo study was performed to evaluate the clinical efficiency of the liquid crystalline gel. Addition of Aerosil to the
gel favored hexagonal phase formation. Viscosity and bioadhesivity increased with an increase in the concentration of Aerosil.
Release of tetracycline was sustained as the concentration of Aerosil increased. Various clinical parameters confirmed the
acceptability and efficiency of this gel system.
Published: September 15, 2006 |
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Keywords: | periodontitis pluronic Aerosil serratiopeptidase clinical study |
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