(+)-Epimaritidine,an alkaloid from Zephyranthes rosea |
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Authors: | Shibnath Ghosal Sushma Razdan |
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Affiliation: | Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Banaras Hindu University, Varanasi 221005, India |
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Abstract: | The isolation and determination, by spectroscopic analyses and chemical correlation, of the structure and stereochemistry of (+)-epimaritidine, a new alkaloid from Zephyranthes rosea, is reported. A facile transformation of maritidine to (+)-epimaritidine is described and the mechanism is appraised in the light of the thermodynamic stability of the latter epimer. (+)-Epimaritidine comprises a missing link in the C-3 epimeric pairs of 5,10b-ethanophenanthridine alkaloids of the vittatine-haemanthamine type. |
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Keywords: | 5,10b-ethanophenanthridine alkaloid (+)-epimaritidine C-3 epimerization. |
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