Sesquiterpenes and alkaloids from Cleistopholis patens |
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Authors: | Peter G. Waterman Ilias Muhammad |
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Affiliation: | Phytochemistry Research Laboratories, Department of Pharmacy (Pharmaceutical Chemistry), University of Strathclyde, Glasgow Gl 1XW, U.K. |
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Abstract: | The root bark of Cleistopholis patens collected in Ghana yielded two sesquiterpenes and five alkaloids. The sesquiterpenes have been characterised as the acyclic methyl-(?)-(trans)-(trans)-10,11-dihydroxyfarnesoate and its monocyclic derivative methyl-(+)-10-hydroxy-6,11-cyclofarnes-7(14)-enoate. The alkaloids were of the unusual aza-polycyclic and naphthyridine groups and included one new member of both classes. Examination of stem bark samples from the same source and from Sierre Leone showed the presence of the sesquiterpenes and the oxoaporphine alkaloid liriodenine but neither of the rarer alkaloid types. |
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Keywords: | Annonaceae sesquiterpenes aza-polycyclic alkaloids onychine cleistopholine naphthyridine alkaloids eupolauridine eupolauridine-N-oxides. |
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