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Biotransformation of tetrahydroberberine to berberine by enzymes prepared from cultured coptis japonica cells |
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| Authors: | Yasuyuki Yamada Naosuke Okada |
| Affiliation: | Research Center for Cell and Tissue Culture, Kyoto University, Kyoto 606, Japan |
| Abstract: | Crude enzymes were extracted from cultured Coptis japonica cells producing large amounts of berberine. One of the enantiomers of tetrahydroberberine, (S)-(?)-tetrahydroberberine, was dehydrogenated to berberine by the enzyme system. |
| Keywords: | Ranunculaceae biotransformation cultured cells stereospecificity alkaloid berberine tetrahydroberberine. |
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