Biosynthesis of piperlongumine |
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Authors: | Bharathi R Prabhu Newand B Mulchandani |
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Institution: | Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Bombay-400085, India |
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Abstract: | The incorporation of l-U-14C]lysine and l-U-14C]phenylalanine into piperlongumine has been demonstrated in Piper longum. The subsequent stepwise degradation to methyl-(3,4,5-trimethoxyphenyl)-propanoate and δ-aminovaleric acid revealed that the C6-C3 moiety of the alkamide arises from phenylalanine; the heterocyclic ring is biosynthesised from lysine. It has also been shown that dl-2-14C]tyrosine and 2-14C]sodium acetate are poor precursors of piperlongumine. |
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Keywords: | Piperaceae alkamides piperlongumine biosynthesis |
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