| 大鼠脑发育不同时期学习记忆的变化及与NMDA受体通道动力 … |
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| 引用本文： | 熊鹰,蔡文琴. 大鼠脑发育不同时期学习记忆的变化及与NMDA受体通道动力 …[J]. 中国应用生理学杂志, 2000, 16(1): 18-21 |
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| 作者姓名： | 熊鹰 蔡文琴 |
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| 作者单位： | [1]第三军医大学生理教研室 [2]第三军医大学组胚教研室 |
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| 摘 要： | 目的：研究大鼠脑发育不同时期学习记忆的变化及与ＮＭＤＡ受体通道动力学特性的关系。方法：采用学习记忆行为和离子通道动力学特性测定相结合的方法。结果：在爬杆主动回避反应中，发育早期大鼠习得和保持能力场明显强于成年大鼠。同时，发育早期大鼠训练后ＮＭ受体ｐＳ导电，而且３５ＰＳ通道开放时间和开放概率增加，３５ＰＳ通道长开放成份增多，有长ｃｌｕｓｔｅｒ开放而砀上大鼠２０Ｓ，３５ＰＳ通道关闭时间常数明显长于年龄
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| 关 键 词： | 发育 学习 记忆 NMDA受体通道 AAR 动力学特性 |
| 修稿时间： | : |
DEVELOPMENTAL CHANGES OF LEARNING, MEMORY AND ITS RELATONSHIP WITH THE KINETIC PROPERTIES OF NMDA RECEPTOR CHANNEL |
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| XIONG Ying,LI Xi cheng,CAI Wen qin ,SUI Jian feng. DEVELOPMENTAL CHANGES OF LEARNING, MEMORY AND ITS RELATONSHIP WITH THE KINETIC PROPERTIES OF NMDA RECEPTOR CHANNEL[J]. Chinese journal of applied physiology, 2000, 16(1): 18-21 |
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| Authors: | XIONG Ying LI Xi cheng CAI Wen qin SUI Jian feng |
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| Affiliation: | XIONG Ying,LI Xi cheng,CAI Wen qin 1,SUI Jian feng |
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| Abstract: | Aim:To investigate the relationship between developmental changes of learning, memory and the kinetic properties of NMDA receptor channel. Methods:To use behaviour training and patch clamp technique. Results:Early developmental rats show the better ability in the acquisition and retention of pole jump active avoidance reaction(AAR) than that of adult rats. After AAR acquisition, 50 pS channel of NMDA receptor emerged in young rats, the open time, open probability, long cluster open components of 35 pS channel was also increased. But the close time constants of NMDA receptor channel of adult rats were longer than that of early deve lopmental rats. Conclusion: The ability of learning and memory was different between early development and adult rats, because of the different changes of the kinetic properties of NMDA receptor channel. |
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| Keywords: | development learning memory NMDA receptor channel |
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