Positional effect of single bulge nucleotide on PNA(peptide nucleic acid)/DNA hybrid stability. |
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| Authors: | N Sugimoto K Yamamoto N Satoh |
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| Affiliation: | Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan. |
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| Abstract: | We report positional effect of bulge nucleotide on PNA/DNA hybrid stability. CD spectra showed that PNA/DNA hybrids required at least seven base pairings at a stem region to form a bulged structure. On the other hand, DNA/DNA could form bulged structure when there are only four base pairings adjacent to the bulge nucleotide. We discuss why PNA requests such a many base pairings to form bulged structure from a nearest neighbor standpoint. |
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