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Polymorphism at the Apical Membrane Antigen 1 Gene (AMA1) of the Malaria Parasite Plasmodium falciparum in a Vietnamese Population |
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| Authors: | Nguyen Duc Quang Phan Thi Phuong Hoa Mai Sy Tuan Nguyen Xuan Viet Amadu Jalloh Hiroyuki Matsuoka |
| Institution: | 1. Laboratory of Molecular Population Genetics, Ehime University, Matsuyama, Japan 2. Laboratory of Molecular Microbial Ecology, Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan 3. Department of Botany, Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam 4. Department of Genetics, Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam 5. Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical School, Minami-Kawachi, Japan |
| Abstract: | The patterns of molecular evolution of the most diverse region of the apical membrane antigen 1 (AMA1) gene in Plasmodium falciparum from a Vietnamese subpopulation (Bao Loc) were investigated. Within the Bao Loc population, the sequenced gene region showed relatively high allelic and nucleotide diversity (0.985 and 0.02694, respectively). Further, the level of population recombination was substantial, resulting in a significant decay of linkage disequilibrium along the gene region. The results suggest that AMA1 is a useful genetic marker for studying the relationships between adaptation of parasite populations (to the human host immune system) and malaria epidemiology. |
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