Reduction of the acetylcholine-induced K+ current in identifiedAplysia neurons by human interleukin-1 and interleukin-2 |
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Authors: | Masashi Sawada Nobumasa Hara Takashi Maeno |
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Institution: | Department of Physiology, Shimane Medical University, Izumo, Japan. |
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Abstract: | 1. Effects of bath-applied recombinant human interleukin-1 (rhIL-1) and interleukin-2 (rhIL-2) on the acetylcholine (ACh)-induced K+ current recorded from identified neurons (R9 and R10) of Aplysia kurodai were investigated with voltage-clamp and pressure ejection techniques. 2. Bath-applied rhIL-1 and rhIL-2 (10-40 U/ml) reduced the ACh-induced current in the neurons without affecting the resting membrane conductance and holding current. 3. The suppressing effects of these cytokines on the current were completely reversible. 4. Heat-inactivated rhIL-1 and rhIL-2 were without effect. 5. These results suggest that the immunomodulators, IL-1 and IL-2, can modulate the ACh-induced response in the nervous system. |
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Keywords: | interleukin-1 interleukin-2 acetylcholine-induced K+ current inhibitory modulation Aplysia neuron |
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