Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data |
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| Authors: | David L Scott Gerold Diez Wolfgang H Goldmann |
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| Institution: | (1) Renal Unit, Leukocyte Biology & Inflammation Program, Structural Biology Program and the Massachusetts General Hospital/Harvard Medical School, 149 13th Street, Charlestown, 02129, MA, USA;(2) Friedrich-Alexander-University of Erlangen-Nuremberg, Center for Medical Physics and Technology, Biophysics Group, Henkestrasse 91, 91052 Erlangen, Germany |
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| Abstract: | Background Over the past decade our laboratory has focused on understanding how soluble cytoskeleton-associated proteins interact with
membranes and other lipid aggregates. Many protein domains mediating specific cell membrane interactions appear by fluorescence
microscopy and other precision techniques to be partially inserted into the lipid bilayer. It is unclear whether these protein-lipid-interactions
are dependent on shared protein motifs or unique regional physiochemistry, or are due to more global characteristics of the
protein. |
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