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Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity |
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| Authors: | Ekaterina A Alyamkina Anastasia S Likhacheva Tamara E Sebeleva Nelly A Popova Elena V Kiseleva Ludmila V Sakhno Alexandr A Ostanin Stanislav N Zagrebelniy Mikhail A Shurdov |
| Institution: | a Novosibirsk State University, Novosibirsk, Russia b Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia c Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia d LLC Panagen, Gorno-Altaisk, Russia |
| Abstract: | Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli. |
| Keywords: | Nucleosome-free fragmented dsDNA Mononuclear cells Lung tuberculosis Allostimulatory activity |
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