Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis |
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| Authors: | Shaohua Deng Yebin Xi Hong Wang Xiaoyin Niu Yue Tao |
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| Institution: | a Department of Immunology, Institutes of Medical Sciences, Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China
b Guanghua Rheumatology Hospital, Shanghai, China |
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| Abstract: | Vasoactive intestinal peptide (VIP) is a well-known anti-inflammatory neuropeptide. The capacity of VIP can be exhibited through inhibiting inflammatory responses, shifting the Th1/Th2 balance in favor of anti-inflammatory Th2 immunity and inducing regulatory T cells (Tregs) with suppressive activity. In addition to pro-inflammatory Th1 response, Th17 are also believed to play important roles in the pathogenesis of rheumatoid arthritis (RA). In this study, we used collagen-induced arthritis (CIA) model in Wistar rats to investigate the role of VIP in the balance of CD4+ CD25+ Tregs and Th17 on RA. Data presented here showed that administration of VIP decreased incidence and severity of CIA. Disease suppression was associated with the upregulation of CD4+ CD25+ Tregs, downregulation of Th17- and Th1-type response and influence on the RANK/RANKL/OPG system. The results provide novel evidence that the therapeutic effects of VIP on CIA rats were associated with the balance of CD4+ CD25+ Tregs and Th17. |
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| Keywords: | Vasoactive intestinal peptide (VIP) CD4+ CD25+ regulatory T cells (Tregs) Th17 Collagen-induced arthritis (CIA) Autoimmune disease |
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