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Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients |
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| Authors: | AP Alegretti T Mucenic GA Faulhaber RM Xavier |
| Institution: | a Serviço de Patologia Clínica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil b Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil c Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Brazil d Serviço de Medicina Interna, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil e Serviço de Hematologia Clinica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil |
| Abstract: | CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with complement inhibitory properties. CD55 inhibits the formation of C3 convertases, and CD59 prevents the terminal polymerisation of the membrane attack complex. It has been reported that SLE patients seems to have an acquired deficiency of these proteins associated with secondary autoimmune haemolytic anaemia and lymphopenia. The aim of this study was to evaluate the presence of altered CD55 and CD59 expression on peripheral blood cells from SLE patients. Flow cytometric analyses were performed on red and white blood cells from 23 SLE patients and 23 healthy controls. We observed more CD55- and CD59-lymphocytes (p = 0.005 and p = 0.019, respectively), and CD59-granulocytes (p = 0.045) in SLE patients than in controls. These results suggest there is an altered pattern of CD55 and CD59 expression on the peripheral blood cells of SLE patients, and it may play a role in the cytopenias in these patients. |
| Keywords: | Systemic lupus erythematosus SLE CD55 CD59 Lymphopenia Cytopenias Complement system GPI Flow cytometry Immunophenotyping |
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