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Synthesis of 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides |
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| Authors: | Du Jinfa Patterson Steven Shi Junxing Chun Byoung-Kwon Stuyver Lieven J Watanabe Kyoichi A |
| Institution: | Pharmasset Inc., 1860 Montreal Road, Tucker, GA 30084, USA. jdu@pharmasset.com |
| Abstract: | Novel racemic 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4-oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid. |
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