Circadian and sleep-deprivation variations of monophosphorylated MAP-Kinase in hypothalamus and pons of rats |
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| Authors: | Stephanie Mijangos-Moreno Alwin Poot-Aké Andrea Sarro-Ramírez Ramsés Jiménez-Moreno Elda Pacheco-Pantoja Pedro Aquino-Hernández |
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| Institution: | 1. Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico;2. Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico;3. Grupo de Investigación en Envejecimiento, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico |
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| Abstract: | Behavior and physiological changes are under the influence of circadian and homeostatic variations. Temporal alignment regulates timing of neurobiological phenomena, such as protein phosphorylation. In the current report, we describe the circadian and sleep homeostatic phosphorylated mitogen-activated protein kinase (MAP-K) variations in hypothalamus and pons of rats across 24 h as well as after sleep deprivation. In the circadian study, MAP-K expression showed a building-up profile during the dark phase in hypothalamus, whereas an increase across the lights-on period was found in pons. On the other hand, that phosphorylation of MAP-K in hypothalamus and pons displayed a significant reduction after sleep rebound period. Data demonstrate that MAP-K phosphorylation undergoes circadian and sleep homeostatic variations in brain areas linked to sleep modulation. |
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| Keywords: | mitogen-activated protein kinase hypothalamus pons Western blot sleep deprivation |
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