Social rhythm and other chronobiological findings in juvenile myoclonic epilepsy |
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| Authors: | RL Schimitt JA Bragatti R Levandovsky MP Hidalgo MM Bianchin |
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| Institution: | 1. Laboratório de Cronobiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Programa de pós-gradua??o em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazilreginalopesschimitt@gmail.com;4. Programa de pós-gradua??o em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;5. Division of Neurology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;6. Programa de pós-gradua??o em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;7. Programa de pós-gradua??o em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;8. Departamento de Psiquiatria e Medicina Legal, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil |
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| Abstract: | We evaluated the correlation between chronobiological variables and characteristics of juvenile myoclonic epilepsy. Sample: 17 individuals epileptic outpatients and respective controls. Instruments: The Social Rhythm Metric for social zeitgebers, lux meter, and an ACT10® thermistor for activity–rest rhythm, light exposure, and peripheral body temperature. Regularity scores showed an inverse correlation with age at disease onset (r = ?0.5; p < 0.05), but not with disease duration or stabilization time. A significant intergroup difference was recorded for mean diurnal peripheral temperature (p < 0.01) and activity amplitude (= 0.06). There was a correlation between activity and temperature means in both groups. These results underscore the relationship between epilepsy and the biological clock on a physiological level. Epilepsy, in turn, is influenced by the circadian rhythm, indicating the potential involvement of the body’s internal clock in the development of the disease or the seizure recurrence pattern. |
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| Keywords: | social rhythm epilepsy chronobiology |
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