Copper(II) and nickel(II) ternary complexes of L-dopa and related compounds |
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Authors: | T Kiss A Gergely |
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Institution: | Department of Inorganic and Analytical Chemistry, Kossuth Lajos University, Debrecen, Hungary |
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Abstract: | The stability constants of the mixed ligand complexes of L-dopa, L-tyrosine, L-phenylalanine, and dopamine with copper(II) and nickel(II) ions and with 2,2'-bipyridyl and 1,10-phenanthroline were determined pH-metrically at 25 degrees C and an ionic strength of 0.2 mol/dm3 (KCl). Spectral studies were made to establish the binding mode of the ambidentate L-dopa in the ternary complexes. In contrast with the aromatic (N,N) donor atoms, the (O,O) binding mode of L-dopa is particularly favored in its ternary systems with copper(II) and nickel(II); thus, even at physiological pH there is a very considerable formation of (O,O)-bound mixed ligand complexes containing a free amino acid side-chain. Numerous binary transition metal-L-dopa complexes and the ternary complexes formed with various B ligands have been evaluated from a coordination chemistry aspect, with regard to the possibility of their therapeutic application in the treatment of Parkinson disease. |
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Keywords: | Dopa L-3 4-dihydroxphenylalanine tyr L-tyrosine phe L-phenylalanine bpy 2 2'-bipyridyl phen 1 10-phenanthroline ala L-alanine glygly glycylglycine pyr pyrocatechol |
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