Membrane specializations and endosome maturation in dendritic cells and B cells |
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Authors: | Boes Marianne Cuvillier Armelle Ploegh Hidde |
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Institution: | Department of Pathology, Harvard Medical School, The New Research Building, Room 836, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. |
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Abstract: | Interest in the cell biology of antigen presentation is centered on dendritic cells (DCs) as initiators of the immune response. The ability to examine primary antigen-presenting cells, as opposed to cell lines, has opened a new window for study of antigen processing and peptide acquisition by Class II major histocompatibility complex (MHC) products, especially where intracellular trafficking of peptide-Class-II complexes is concerned. Here, we review the dynamics of Class II MHC-positive intracellular structures in dendritic cells as well as B cells. We focus on the generation of multivesicular bodies, where Class II MHC products acquire antigenic peptide, on the endosomal transport of peptide-loaded Class II MHC to the cell surface and on the importance of Class II MHC localization in membrane microdomains. |
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