Nonspecific electrostatic binding characteristics of the heparin-antithrombin interaction |
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| Authors: | Seyrek Emek Dubin Paul L Henriksen Jens |
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| Institution: | Department of Chemistry, Indiana University Purdue University Indianapolis, 402 N. Blackford St. Indianapolis, IN 46202, USA. |
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| Abstract: | We evaluated the role of nonspecific electrostatic binding in the interaction of antithrombin (AT) with heparin (Hp), a paradigmatic protein-glycosaminoglycan (GAG) system. To do so, we obtained the ionic-strength dependence of the binding constant, since a common feature in protein-polyelectrolyte systems is a maximum in affinity in the ionic strength range 10 mM
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| Keywords: | heparin antithrombin electrostatics ionic strength selectivity and specificity |
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