Effect of hormones on cyclic AMP levels in cultured human cells. |
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Authors: | D Dixon-Shanies J L Knittle |
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Affiliation: | Division of Nutrition and Metabolism, Department of Pediatrics, Mount Sinai School of Medicine, New York, N. Y. 10029 USA |
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Abstract: | Cultured cells derived from human adipose tissue grew more slowly and had significantly higher basal levels of cyclic AMP than cultured fibroblasts. Cyclic AMP levels in cultured adipose tissue cells were unaffected by epinephrine and were elevated 15-fold by prostaglandin E1 while fibroblast cyclic AMP levels were elevated 27-fold by epinephrine and 95-fold by prostaglandin E1. These results support the postulate that the cultured adipose tissue cell is a distinct cell type which may represent an adipocyte or preadipocyte in culture. |
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