Engineered cardiac tissues |
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| Authors: | Iyer Rohin K Chiu Loraine L Y Reis Lewis A Radisic Milica |
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| Affiliation: | 1Institute of Biomaterials and Biomedical Engineering, 164 College St., Rosebrugh Building, University of Toronto, Toronto, Ontario, Canada M5S 3G9;2Department of Chemical Engineering and Applied Chemistry, 200 College St., University of Toronto, Toronto, Ontario, Canada M5S 3E5;3Heart & Stroke/Richard Lewar Centre of Excellence, 150 College St., University of Toronto, Toronto, Ontario, Canada M5S 3E2 |
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| Abstract: | Cardiac tissue engineering offers the promise of creating functional tissue replacements for use in the failing heart or for in vitro drug screening. The last decade has seen a great deal of progress in this field with new advances in interdisciplinary areas such as developmental biology, genetic engineering, biomaterials, polymer science, bioreactor engineering, and stem cell biology. We review here a selection of the most recent advances in cardiac tissue engineering, including the classical cell-scaffold approaches, advanced bioreactor designs, cell sheet engineering, whole organ decellularization, stem cell-based approaches, and topographical control of tissue organization and function. We also discuss current challenges in the field, such as maturation of stem cell-derived cardiac patches and vascularization. |
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