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New azobenzene derivatives for directed modification of proteins |
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| Authors: | Le Thi Hien B. Schierling A. Yu. Ryazanova T. S. Zatsepin E. M. Volkov E. A. Kubareva T. I. Velichko A. Pingoud T. S. Oretskaya |
| Affiliation: | (1) State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China;(2) College of Chemistry, Beijing Normal University, Beijing, 100875, People’s Republic of China;(3) The Key Laboratory of Transformation of Natural Gas, Ningxia University, Yinchuan, 750021, People’s Republic of China; |
| Abstract: | Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free form and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied. |
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