Horizontal Gene Transfers in prokaryotes show differential preferences for metabolic and translational genes |
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Authors: | Aditi Kanhere and Martin Vingron |
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Institution: | (1) Max Planck Institute for Molecular Genetics, Ihnestra?e 63–73, 14195 Berlin, Germany;(2) MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, W1T 4JF, UK |
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Abstract: | Background Horizontal gene transfer (HGT) is an important process, which contributes in bacterial pathogenesis and drug resistance. A
number of methods have been proposed for detection of horizontal gene transfer. One successful approach to the detection of
HGT events is due to Novichkov et al. (J. Bacteriology 186, 6575–85), who rely on comparing phylogenetic distances within a gene family with genomic distances
of the source organisms. Building on their approach, we introduce outlier detection in the correlation between those two sets
of distances. This approach is designed to detect horizontal transfers of core set of genes present in many bacteria. The
principle behind method allows detection of xenologous gene displacements as well as acquisition of novel genes. |
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Keywords: | |
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