Comprehensive characterization of neuroblastoma cell line subtypes reveals bilineage potential similar to neural crest stem cells |
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Authors: | Sandra Acosta Cinzia Lavarino Raquel Paris Idoia Garcia Carmen de Torres Eva Rodríguez Helena Beleta Jaume Mora |
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Affiliation: | 1. Developmental tumor biology laboratory, Hospital Sant Joan de Déu., Passeig Sant Joan de Déu, 2, 08950, Esplugues de Llobregat, Barcelona, Spain
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Abstract: | Background Neuroblastic tumors (NBT) derive from neural crest stem cells (NCSC). Histologically, NBT are composed by neuroblasts and Schwannian cells. In culture, neuroblastic (N-), substrate-adherent (S-) and intermediate phenotype (I-) cell subtypes arise spontaneously. |
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