Toxic effect of heavy metals on cells isolated from the rat adrenal and testis |
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Authors: | T B Ng W K Liu |
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Institution: | (1) Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong;(2) Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong |
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Abstract: | Summary Heavy metals including mercury, cadmium, cobalt, and copper (100 μM) exerted an adverse effect on the viability of isolated rat adrenal capsular (zona glomerulosa), adrenal decapsular (fasciculata
and reticularis), and Leydig cells of the testis with mercury being the most potent. Due to the decreased cell viability there
was a parallel reduction in corticotropin-stimulated, corticosterone production by adrenal decapsular cells and luteinizing
hormone-stimulated testosterone production by Leydig cells. The results indicated a direct toxic action of these heavy metals
on steroid-producing cell in the adrenal gland and the tectis. Other metals tested, including lead, zinc, aluminum, chromium,
iron, nickel, and lithium, did not exert any deleterious effect on cell viability or hormone-induced steroidogenesis, in adrenal
and Leydig cells when tested up to a concentration of 100 μM. |
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Keywords: | Leydig cells adrenal cells steroidogenesis heavy metals |
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