Bovine lens aldose reductase: identification of two enzyme forms |
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| Authors: | A Del Corso D Barsacchi M Camici D Garland U Mura |
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| Institution: | Department of Physiology and Biochemistry, University of Pisa, Italy. |
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| Abstract: | Two structurally different forms of bovine lens aldose reductase have been identified. Freshly prepared lens extracts contain an unactivated "b form" (ARb) which is sensitive to inhibition by Sorbinil. Upon incubation of the extracts with oxygen radical generating systems, ARb is converted to a more active "a form" (ARa), which is not inhibited by Sorbinil. ARa and ARb were purified to electrophoretic homogeneity. |
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