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Enantioseparation of racemic amlodipine using immobilized ionic liquid by solid-phase extraction |
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| Authors: | Min Liu Zhong-Qian Liu Hai Zhu Chao-Hong He Ke-Jun Wu |
| Institution: | 1. Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
Institute of Zhejiang University-Quzhou, Quzhou, China;2. Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China;3. School of Chemical and Process Engineering, University of Leeds, Leeds, UK |
| Abstract: | In this paper, a novel l -glutamate based immobilized chiral ionic liquid (SBA-IL (Glu)) was prepared by chemical bonding method and applied as a solid sorbent for chiral separation of amlodipine. The performance of SBA-IL (Glu) was investigated for the absorption of (S)-amlodipine and separation of amlodipine enantiomer. The static experiment showed that equilibrium adsorption was achieved within 80 minutes, and the saturation adsorptions capacity was 12 mg/g. The complex was then packed in a glass chromatographic column for the separation of amlodipine and the enantiomeric excess (%ee) of (S)-amlodipine reached 24.67%. The immobilized ionic liquids exhibit good reusability, and the separation efficiency remains 18.24% after reused five times, which allows potential scale-up for the chiral separation of amlodipine. |
| Keywords: | amlodipine enantioseparation immobilized amino ionic liquid solid-phase extraction |