Multifunctional chiral aminophosphines for enantiodivergent catalysis in a palladium-catalyzed allylic alkylation reaction |
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| Authors: | Sviatoslav S Eliseenko Mohan Bhadbhade Fei Liu |
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| Institution: | 1. Department of Molecular Sciences, Macquarie University, Sydney, New South Wales, Australia;2. Solid State & Elemental Analysis Unit, Mark Wainwright Analytical Centre, Division of Research, The University of New South Wales, Sydney, New South Wales, Australia |
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| Abstract: | Trifunctional MAP-based chiral phosphines were tested as new ligands in a Pd-catalyzed asymmetric allylic alkylation, demonstrating fast and enantiodivergent catalysis. The palladium complexes of representative ligands by X-ray analysis revealed a novel mode of P,N-coordination of the ligand to the palladium center, which may contribute to switching the sense of the asymmetric induction via combined steric and tunable H-bonding interactions between the metal complex and the substrates. |
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| Keywords: | catalytic dualism enantiodivergent catalysis H-bonding ligands |
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