Neurochemistry of GABAergic System in Cerebral Cortex Chronically Exposed to Bromide In Vivo |
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| Authors: | Vladimir J. Balcar,Sandor L. Erdö ,Ferenc Joó &dagger ,Pé ter Ká sa&Dagger ,Joachim R. Wolff |
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| Affiliation: | Centre of Anatomy, Georg August University, Göltingen, F.R.G.;Pharmacological Research Centre, Chemical Works of Gedeon Richier Ltd., Budapest;Laboratory of Molecular Neurobiology, Institute of Biophysics of the Hungarian Academy of Sciences, Szeged;Central Research Laboratory, University Medical School, Szeged, Hungary |
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| Abstract: | Neurochemical correlates of GABAergic synaptic transmission [binding, uptake, metabolism, and tissue content of gamma-aminobutyric acid (GABA)] were investigated in the cortex of rats that had been given 27 mM bromide in drinking water for periods of time ranging from 1 day to 1 month. No effect of bromide on any of the parameters was found and it is concluded that chronic administration of bromide has no profound effect on GABAergic inhibitory system in the rat cortex. |
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| Keywords: | GABAergic synaptic transmission Bromide Rat cerebral cortex |
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