Immunostimulatory Activities of the Sulfated Polysaccharide Ascophyllan from Ascophyllum nodosum in in Vivo and in Vitro Systems |
| |
Authors: | Kiyoaki Nakano Daekyung Kim Zedong Jiang Mikinori Ueno Takasi Okimura Kenichi Yamaguchi Tatsuya Oda |
| |
Affiliation: | Division of Biochemistry, Faculty of Fisheries, Nagasaki University. |
| |
Abstract: | Splenic natural killer (NK) cell activity against YAC-1 cells increased in mice intraperitoneally injected with ascophyllan. Ascophyllan enhanced the cytotoxicity of RAW264.7 cells toward YAC-1 cells in a concentration-dependent manner. The cytotoxicity of ascophyllan-stimulated RAW264.7 cells as to YAC-1 cells was suppressed with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME), an inhibitor of nitric oxide (NO) synthase, suggesting the involvement of NO in the cytotoxicity of ascophyllan-stimulated RAW264.7 cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|