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Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli. |
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| Authors: | W A Rosche A Jaworski S Kang S F Kramer J E Larson D P Geidroc R D Wells R R Sinden |
| Abstract: | The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded-DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats. |
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