Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin. |
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| Authors: | H Kasai Z Yamaizumi F Yamamoto T Bessho S Nishimura M Berger J Cadet |
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| Affiliation: | Biology Division, National Cancer Center Research Institute, Tokyo, Japan. |
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| Abstract: | Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA. |
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