Modulation of fluoropyrimidine metabolism by chlorpromazine |
| |
| Authors: | A Tseng M Brooks E Cadman |
| |
| Affiliation: | 1. Department of Mechanical Engineering, Delhi Technological University, Delhi, 110042, India;2. Mechanical Engineering Department, Galgotias College of Engineering and Technology, Greater Noida, 201306, UP, India;1. School of Environment, Harbin Institute of Technology, Harbin 150090, China;2. School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, China;1. Department of Materials Science and Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh;2. Department of Electrical and Electronic Engineering, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh |
| |
| Abstract: | Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs. Using S-180 murine sarcoma cells, the accumulation of the base Fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as measured by HPLC. In contrast, the accumulation and metabolism of the nucleoside Fluorouridine was suppressed by chlorpromazine. Cytotoxicity studies revealed that non-toxic concentrations of chlorpromazine were synergistic with Fluorouracil, but were antagonistic with Fluorouridine. These findings suggest that modulation by chlorpromazine of specific nucleoside kinase involved in Fluorouracil metabolism can result in increased therapeutic utility. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
