A Modified CDC Biofilm Reactor to Produce Mature Biofilms on the Surface of PEEK Membranes for an In Vivo Animal Model Application |
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| Authors: | Dustin L Williams Kassie L Woodbury Bryan S Haymond Albert E Parker Roy D Bloebaum |
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| Institution: | (1) Department of Bioengineering, University of Utah, Salt Lake City, UT, USA;(2) Department of Veterans Affairs, Bone and Joint Research Laboratory (151F), Salt Lake City, UT, USA;(3) Center For Biofilm Engineering, Montana State University, Bozeman, MT, USA;(4) Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT, USA |
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| Abstract: | Biofilm-related infections have become a major clinical concern. Typically, animal models that involve inoculation with planktonic
bacteria have been used to create positive infection signals and examine antimicrobial strategies for eradicating or preventing
biofilm-related infection. However, it is estimated that 99.9% of bacteria in nature dwell in established biofilms. As such,
open wounds have significant potential to become contaminated with bacteria that reside in a well-established biofilm. In
this study, a modified CDC biofilm reactor was developed to repeatably grow mature biofilms of Staphylococcus aureus on the surface of polyetheretherketone (PEEK) membranes for inoculation in a future animal model of orthopaedic implant biofilm-related
infection. Results indicated that uniform, mature biofilms repeatably grew on the surface of the PEEK membranes. |
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