Effect of the Antimicrobial Peptide Tritrpticin on the In Vitro Viability and Growth of <Emphasis Type="Italic">Trichomonas vaginalis</Emphasis> |
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Authors: | Veronica V Infante Alma D Miranda-Olvera Luis M De Leon-Rodriguez Fernando Anaya-Velazquez Mayra C Rodriguez Eva E Avila |
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Institution: | (1) Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Colonia Noria Alta, Guanajuato, GTO, CP 36050, Mexico;(2) Division de Ciencias Naturales y Exactas, Departamento de Quimica, Universidad de Guanajuato, Guanajuato, CP 36050, Mexico; |
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Abstract: | Antimicrobial peptides are widely distributed in nature; they play important roles in several aspects of innate immunity and
may provide a basis for the design of novel therapeutic agents. In this study, C-amidated tritrpticin, a 13 amino acid tryptophan-rich
antimicrobial peptide derived from a porcine cathelicidin, was tested against Trichomonas vaginalis, a protozoan that causes a serious non-viral sexually transmitted disease associated with preterm birth, low birth weight,
and high risk of HIV-1 infection. Tritrpticin was selected due to its reasonably easy synthesis and because analogs with lower
toxicity may be designed. Our results show that tritrpticin-NH2 at either 100 or 200 μg/ml (52.5 or 105 μM) clearly reduces the viability and growth of Trichomonas vaginalis. Together with tritrpticin-NH2, sodium bicarbonate further limited trichomonad growth. Additionally, a low concentration of metronidazole (5.8 μM), the
most commonly used medication for Trichomonas vaginalis, was more effective against the growth of the parasite when it was combined with tritrpticin-NH2. |
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