Ca modulates outward current throughI
K1 channels |
| |
| Authors: | Michele Mazzanti Louis J DeFelice |
| |
| Institution: | (1) Department of Anatomy and Cell Biology, Emory University School of Medicine, 30322 Atlanta, Georgia |
| |
| Abstract: | Summary Inward-rectifier channels in cardiac cells (I
K1) stabilize the resting membrane potential near the K equilibrium potential. Here we investigate the role ofI
K1 in the regulation of action potentials and link this to the influx of Ca during beating. Inward Ca current alters the open-channel probability of outwardI
K1 current. Thus Ca ions depolarize cells not only by carrying an inward current but also by blocking an outward current. |
| |
| Keywords: | heart cells potassium channels inward-rectifier calcium channels action potential modulation |
| 本文献已被 SpringerLink 等数据库收录！ |
